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Premium Coleus Forskohlii Extract (Forskolin ≥98% HPLC) - Lab-Tested Purity for Enhanced Bioactivity
Ideal for research and development within the pharmaceutical, nutraceutical, and healthcare industries, supporting applications in metabolic, cardiovascular, and inflammatory health areas.
Product Name :
ForskolinCAS No. :
66575-29-9Appearance :
Light yellow to white crystalline powderSpecification :
10%-98%CAS: 66575-29-9
Molecular Formula: C??H??O?
Molecular Weight: 410.50
Appearance: Light yellow to white crystalline powder
Multi-Concentration Flexibility & Clinically Driven Efficacy
≥98% Pure: Pharmaceutical/Cosmetic Grade (HPLC-verified)
10%-98% Blends: Customizable for nutraceuticals, topical formulations, and functional cosmetics
Adenylate Cyclase Activation: Unique direct activator of cAMP pathways, modulating cellular repair and anti-inflammatory responses.
Anti-Inflammatory & Skin Barrier Repair:
Reduces transepidermal water loss by 32% and accelerates keratinocyte migration by 300%, enhancing epidermal regeneration in atopic skin. Inhibits UV-induced COX-2 expression by 80% at 2.0% concentration, preventing photoaging and collagen degradation.
Anti-Acne & Sebum Regulation:
Suppresses P. acnes growth (MIC: 1.5 mg/mL) via bacterial DNA synthesis inhibition and normalizes sebum production by 25% in oily skin formulations.
Antioxidant & Anti-Pollution Defense:
Neutralizes PM2.5-induced ROS by 40% and blue light-generated free radicals by 50%, outperforming standard antioxidants like vitamin E.
Anti-Cellulite & Firming Action:
Activates lipolysis in adipocytes, reducing thigh circumference by 3.2 cm in 12-week human trials (0.1% serum formulation).
| Parameter | Detail |
|---|---|
| Purity Range | 10%, 20%, 50%, 98%+ (HPLC-ELSD) |
| Source | Coleus forskohlii aerial parts (GACP-certified farms, Yunnan, China) |
| Extraction Method | Ethanol-based resin chromatography + preparative HPLC |
| Solubility | Ethanol, DMSO, PG; insoluble in water |
| Storage | -20°C in argon-sealed vials (24-month stability) |
| Heavy Metals | ≤10 ppm (USP/EP compliant) |
| Key Impurities | Isoforskolin ≤0.5% (HPLC-controlled) |
? Anti-Aging Serums:
Synergizes with hyaluronic acid and peptides to boost collagen I synthesis by 40%, targeting wrinkles and skin laxity.
? Acne & Sensitive Skin Formulations:
Reduces redness and irritation by 60% in cleansers, paired with Boswellia extracts for barrier repair.
? Weight Management Supplements:
Enhances thermogenesis in nutraceutical capsules (10-20% blends), increasing metabolic rate by 18%.
?? Post-Sun Recovery Gels:
Repairs UV-damaged DNA and soothes solar erythema at 1.0-4.0% concentrations.
?? Bioactivity-Optimized Extraction:
Ultrasound-Assisted Ethanol Extraction: Yields 92% vs. 60% conventional methods, preserving thermolabile diterpenes.
Macroporous Resin Purification: Achieves >98% purity by removing pigments (e.g., 2,6,11,15-tetramethyl-hexadecadienedial).
? Enhanced Delivery Systems:
Nanoemulsion Carriers: 8× skin penetration boost (QTY: 4.1 μg/cm² vs. 0.5 μg/cm² conventional) for targeted cAMP activation.
? Certified Quality & Sustainability:
ISO 9001/Kosher/Halal certified. Traceable from farm to batch (COA with Forskolin/Isoforskolin ratio).
| Cargo Weight | Packaging Method | Shipping | Lead Time |
|---|---|---|---|
| 1–25 kg | Vacuum-sealed foil bags + drum | DHL/FedEx | 7 days |
| 25–500 kg | Pharma-grade HDPE drums | Air freight | 10–15 days |
| >500 kg | Temperature-controlled pallets | Sea freight | 30–55 days |
How to verify Forskolin authenticity?
Free 20g samples with batch-specific COA (HPLC at λmax 305 nm, tR: 6.3 min) .
Stability in cosmetic bases?
Maintains >90% potency for 18 months in pH 5.0–7.0 creams; avoid strong oxidizers and high temperatures.
Custom derivatives available?
Yes—PEGylated Forskolin for sustained-release serums, and alkylated variants (C8-C12) for oil-soluble formulations.
? Ethical & Eco-Conscious Sourcing:
Coleus forskohlii from regenerative farms in Yunnan, China (wild-simulated cultivation, 0 pesticide residue).
? End-to-End Innovation:
OEM services for enteric-coated nutraceuticals, nanoemulsion complexes, and private-label cosmeceuticals.
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