Molecular Distinction: The Science of 3’-Deoxyadenosine Structural SuperiorityCordycepin (C??H??N?O?), a rare nucleoside analog, mimics adenosine yet resists degradation due to its 3’-deoxy structure. This enables unique bioactivity: Source: Journal of Biological Chemistry 2023 Advanced Extraction & Verification Patented Purification ProtocolOur vertically integrated process ensures uncompromised quality: Cultivation: Cordyceps militaris grown in controlled bioreactors (ISO 14644-1 Class 8) Extraction: Supercritical CO? + UHPLC isolation (>98% purity) Verification: HPLC-ELSD/PDA: Quantification (1%-99% customizable) LC-MS/MS: Confirms molecular identity (m/z 252.1 → 136.0) NMR: Validates stereochemical purity (¹H/¹³C) Impurity Control Residual solvents: <10ppm (ICH Q3C compliant) Heavy metals: <0.5ppm (Pb/Cd/As/Hg) Mechanisms of Action: Evidence-Based Efficacy Anti-Tumor Activity Cordycepin selectively accumulates in cancer cells via ENT1 transporters, inducing:? Apoptosis: Caspase-3/7 activation (IC?? = 28μM in A549 cells)? Metastasis Suppression: MMP-9 downregulation (72% inhibition at 50μM)In vivo data: 57% tumor volume reduction vs. controls (Zebrafish xenograft model) Immunomodulation · Enhances NK cell activity by 230% (10mg/kg dose in murine models)· Inhibits NLRP3 inflammasome → Reduces cytokine storms Metabolic & Anti-Fatigue Effects · AMPK-mediated glucose uptake ↑ 300% (L6 myotubes)· ATP regeneration ↑ 45% in exhaustive exercise models Stability Engineered for Real-World Performance Challenge: Cordycepin degrades rapidly in heat/pH >7.0Our Solution: Nano-Encapsulation: Chitosan coating extends half-life by 5x Storage Protocol: Formulation Guidance: Compatible with enteric coatings, lipid carriers Technical Specifications Parameter Specification Purity (HPLC-ELSD) 1%, 3%, 5%, 7%, 21%, 50%, 98%+ Appearance White cryst. (≥98%) / Brown pow. (<50%) Solubility DMSO >100mg/ml; Water <1mg/ml Bioactivity AMPK EC?? = 0.8μM Cross-Industry Applications Sector Formula Integration Mechanistic Role Pharma Intermediates Oncolytic drug conjugates Telomerase inhibitor Nutraceuticals Sublingual tablets / Sports gels ATP booster + Anti-fatigue Cosmeceuticals Acne serums (0.5-2%) Anti-inflammatory / Sebum control Animal Health Poultry feed additive (100ppm) Antibiotic alternative Competitive Advantages ? Batch-to-Batch Consistency RSD <2.0% for 98% purity grade (n=20 batches)? Scalable & Compliant· GMP-aligned facility (Weifang Huazhi subsidiary)· Kosher/Halal/ISO 9001 certifications? Research-Ready Support· Free cell-based assay data (e.g., IC?? on 12 lines)· Custom molecular docking studies Download Resources:[? Cordycepin Mechanism of Action Dossier] • [? HPLC/MS Spectral Library]Science you can formulate with. Nature you can trust. Key Differentiators Precision: UHPLC isolation eliminates psoralen-like contaminants Potency: 3D cell-validated bioactivity (vs. 2D industry standard) Partnership: Co-development of cordycepin-derivatives (e.g., Cordycepin-5’-triphosphate)

For over 2,000 years, Astragalus membranaceus (Huangqi) has been revered in Traditional Chinese Medicine as the "Supreme Qi-Tonifying Herb." Modern science now validates its legendary status through cycloastragenol (CAG)—a bioactive tetracyclic triterpenoid that exemplifies nature’s power to combat aging, immune dysfunction, and chronic disease. As a premier manufacturer of plant extracts, we unlock this potent compound using cutting-edge purification technologies to deliver >98% purity for global health innovations. Botanical Origin and Chemical Profile Cycloastragenol is the aglycone of astragaloside IV, isolated from the roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus. This small molecule (C??H??O?, MW: 490.72) features a unique 9,19-cyclolanostane structure with four hydroxyl groups critical to its bioactivity. Our extraction process preserves its integrity through: Ethanol/water gradient extraction followed by chromatographic purification Strict QC protocols: HPLC-DAD/ELSD validation, NMR and mass spectrometry confirmation7 Stability optimization: -20°C storage in amber vials to prevent degradation Table 1: Key Specifications of Our Cycloastragenol Parameter Specification CAS No. 78574-94-4 / 84605-18-5 Purity ≥98% (HPLC) Appearance White to off-white crystalline powder Storage -20°C, desiccated Biological Activity Telomerase activation, CTSB inhibition Dual Mechanisms of Action: From Telomeres to Tumor Immunity 1. Telomerase Activation & Anti-Aging Effects Cycloastragenol is nature’s first documented telomerase activator. By binding the catalytic site of telomerase reverse transcriptase (TERT), it: Extends telomeres in CD4+/CD8+ T-cells, delaying replicative senescence Upregulates tert and bcl2 mRNA in neuronal cells, protecting against oxidative stress Enhances antiviral immunity by 300% in human T-lymphocytes (in vitro) This mechanism underpins its potential in age-related disorders—from skin rejuvenation to neuroprotection. 2. Immuno-Oncology: Unblocking MHC-I Antigen Presentation Groundbreaking 2022 research revealed cycloastragenol’s cancer-fighting secret: it directly targets cathepsin B (CTSB) at residues A77/G198. This interaction: Blocks MHC-I degradation in lysosomes, increasing tumor antigen presentation Elevates immunogenic genes (*H2-k1*, B2m, CD74) by 3–5-fold per scRNA-seq data Synergizes with anti-PD-1 therapy, shrinking colon tumors by 60% vs. monotherapy in murine models "CAG reshapes the tumor microenvironment—it’s a ‘checkpoint inhibitor enhancer’ for cold tumors." — Journal for Immunotherapy of Cancer, 2022 Applications in Modern Therapeutics Validated in peer-reviewed studies, cycloastragenol holds promise for: Age-delay supplements: Doubles telomerase activity at 1 μM (6-day exposure Oncology adjuvants: 10 mg/kg/day dosing with PD-1 antibodies boosts CD8+ T-cell infiltratio Neuroprotective agents: Induces CREB phosphorylation to alleviate depression-like behaviors Anti-inflammatory formulations: Suppresses NLRP3 inflammasomes in psoriasis models Quality Commitment We ensure pharmaceutical-grade cycloastragenol through: Bioactivity assays: Telomerase activation (TRAP assay), CTSB binding (MST validation) Traceability: Sustainable sourcing from GAP-certified Astragalus farms Scalability: 50–1000 kg batches with COA, stability data, and customs documentation The Future Is Natural Cycloastragenol bridges ancient wisdom and 21st-century science. As clinical trials explore its potential in longevity and combo oncology therapies, we provide the purest, most bioactive CAG to fuel breakthroughs. Partner with us to co-develop formulations that redefine healthspan

For centuries, Psoralea corylifolia (commonly known as Bakuchi) has been revered in Ayurveda and Traditional Chinese Medicine. Today, its potent bioactive compound—Bakuchiol (C??H??O)—stands at the forefront of cutting-edge cosmetic and nutraceutical research. Extracted from the seeds of this resilient legume, Bakuchiol combines ancient wisdom with validated scientific benefits to deliver multifunctional solutions for modern health and beauty challenges. Unlocking Bakuchiol’s Science-Backed Mechanisms 1. Longevity & Cellular Resilience via DAF-16/FOXO PathwayGroundbreaking research reveals Bakuchiol’s profound anti-aging properties. In C. elegans (a model organism for aging studies), Bakuchiol at 37.5 μM extends lifespan by 38% by activating the evolutionarily conserved IIS/DAF-16 pathway. This triggers: Nuclear translocation of DAF-16 (homologous to human FOXO1), enhancing stress-response gene expression. Upregulation of SOD-3 (superoxide dismutase), boosting antioxidant capacity by 2.3× and combating oxidative damage . Dose-dependent protection against heat and ROS-induced stress, independent of gut microbiota. 2. Multi-Targeted Bioactivity for Holistic ApplicationsBakuchiol’s small molecular structure enables versatile interactions with biological targets: Skin Regeneration: Stimulates collagen synthesis, inhibits matrix metalloproteinases (reducing wrinkles), and suppresses tyrosinase (brightening skin). Antimicrobial Action: Disrupts membranes of S. aureus, E. coli, and C. albicans. Anti-Inflammatory & Estrogenic Effects: Modulates TNF-α/IL-1β and shows potential for bone health . Why Purity ≥99% Is Non-Negotiable Raw Psoralea corylifolia extract contains phototoxic furanocoumarins (e.g., psoralen, isopsoralen), which pose significant safety risks. Our advanced purification process ensures: Ultra-Pure Bakuchiol (≥99%): Using low-pressure supercritical CO? extraction followed by ethanol solvent separation, alkali treatment, and dynamic resin chromatography to eliminate allergens and toxins. Zero Residual Solvents: Unlike petroleum ether/acetate methods, our green technology avoids toxic contaminants. Stability & Scalability: Optimized for industrial production without compromising efficacy. Bakuchiol in Modern Applications Sector Benefits Formulations Cosmetics Retinol-alternative (anti-aging, acne control); non-irritating, photo-stable, suitable for sensitive skin Serums, creams, sunscreens Nutraceuticals Antioxidant/anti-inflammatory support; bone health enhancement Capsules, functional foods Clinical Antimicrobial wound care; depigmentation therapy Gels, ointments Commitment to Sustainability & Efficacy Ethical Sourcing: Psoralea corylifolia is not endangered (IUCN status: Least Concern) and is cultivated under strict ecological guidelines. Clinical Validation: Bakuchiol matches retinol’s efficacy in improving skin elasticity and hyperpigmentation, with 44% less irritation in clinical trials. Global Compliance: EU/Korea/Japan-approved cosmetic ingredient; meets ISO 16128 standards for natural origin. Elevate your formulations with Bakuchiol—where nature’s resilience meets precision science. Contact us to integrate this award-winning, clinically proven extract into your next-generation skincare, wellness, or therapeutic products. Learn more about our CO? extraction technology or request a certificate of analysis → References: Biochemical and Biophysical Research Communications (2025); Sytenol® A Dossier; Chinese Pharmacopoeia (2020).

NANJING, China – June 6, 2025 – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is excited to announce its participation in the world's leading pharmaceutical trade event, CPHI Shanghai 2025. Mark your calendars! We will be exhibiting from June 24th to 26th, 2025 at the Shanghai New International Expo Centre (SNIEC).Visit us at Booth: E5G56 This premier gathering unites the global pharmaceutical community, and Nanjing Spring & Autumn Biological Engineering looks forward to connecting with industry partners, existing clients, and potential collaborators. Our team will showcase our latest innovative solutions and comprehensive portfolio within the bio-engineering sector. Why Visit Our Booth (E5G56): Discover our expertise in [Briefly specify your specialty, e.g., advanced enzyme technologies, peptide synthesis, high-purity biochemicals, fermentation solutions – Customize as needed]. Explore partnership opportunities tailored to your project requirements. Learn about our commitment to quality standards, R&D innovation, and customer-focused service. Engage directly with our technical specialists and business development team. As a key platform for pharmaceutical sourcing and networking, CPHI Shanghai 2025 offers unparalleled insights into industry advancements. Discover how Nanjing Spring & Autumn Biological Engineering can become your strategic partner. We warmly welcome you to meet us at Booth E5G56! Event Details: Event: CPHI Shanghai 2025 Dates: June 24–26, 2025 Location: Shanghai New International Expo Centre (SNIEC), China Our Booth: E5G56 Learn more about our capabilities: [m.wshc888.com]

Nanjing, China – June 27, 2025 – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is pleased to announce its successful participation at CPHI Shanghai, held from June 24th to 26th, 2025. Our team actively engaged with valued existing clients and welcomed numerous promising new domestic prospects at our booth. The event provided an excellent platform to strengthen relationships and showcase our capabilities in the biological engineering sector. We are grateful for the connections made and productive discussions held throughout the exhibition. Nanjing Spring & Autumn looks forward to building on these interactions and continuing to serve the evolving needs of the industry.

Nanjing, China – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is proud to announce the successful attainment of the ISO 9001:2015 Quality Management System certification. This milestone underscores our unwavering commitment to excellence, operational efficiency, and customer satisfaction across our biological engineering solutions. The ISO 9001 certification validates our systematic approach to quality control, continuous improvement, and adherence to international standards. It reflects our dedication to delivering consistent, high-quality products and services to clients worldwide. We extend heartfelt congratulations to our entire team for their rigorous efforts in achieving this globally recognized standard. Nanjing Spring & Autumn remains steadfast in our mission to advance quality-driven innovation in the biotechnology sector.

Nanjing, China  – Nanjing Spring & Autumn Biological Engineering Co., Ltd. proudly announces the successful attainment of Environmental Impact Assessment (EIA) certification, a critical milestone underscoring our dedication to sustainable operations and ecological responsibility. This certification validates our compliance with stringent environmental standards across manufacturing, R&D, and waste management processes. It reflects our proactive approach to minimizing ecological footprints while advancing cutting-edge biological engineering solutions. As an ISO 9001-certified leader in biotechnology, this achievement further demonstrates our integrated commitment to quality, safety, and planetary stewardship. We will continue to innovate responsibly, aligning industrial growth with environmental preservation.

Nanjing, China  – Nanjing Spring & Autumn Biological Engineering Co., Ltd. is honored to announce its official recognition as a Science and Technology Small and Medium-sized Enterprise (SME) by Jiangsu Provincial authorities. This prestigious designation validates our innovative capabilities and technological excellence in the biological engineering sector. As a dual-certified organization (ISO 9001 and EIA) with growing R&D achievements, this status acknowledges our commitment to advancing biotechnological solutions through cutting-edge research and development. It positions us among Jiangsu's most promising technology-driven enterprises, qualifying for enhanced innovation support and policy incentives. This achievement reflects our team's dedication to transforming scientific discovery into industrial applications. We extend gratitude to all employees and partners who contribute to our innovation ecosystem. Nanjing Spring & Autumn remains steadfast in its mission to drive technological progress and sustainable growth within China's biotechnology landscape.